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Center for Metabolic Regulation Research Investigators

The Metabolic Regulation Working Group fosters novel approaches and collaborations to address problems in an integrated and multidisciplinary manner. Coordination with clinical services such as the Obesity-Diabetes Center and individual clinicians dealing with patients affected by these conditions, provides intellectual stimulation and lays the foundation for translational research to rapidly put ideas to practice. 

Core Faculty

Name

Affiliations

Major Research Interests

Gregory L. Braden, MD

  • Associate Professor, Internal Medicine, Tufts University School of Medicine

  • Chief, Division of Nephrology, Baystate Medical Center

  • Neuroendocrine and metabolic regulation of energy balance

  • Effects of obesity on renal function

Grace Makari-Judson, MD

  • Associate Professor, Internal Medicine, Tufts University School of Medicine

  • Medical Director, Comprehensive Cancer Center, Baystate Medical Center

  • Metabolic long-term consequences of breast cancer treatments, with focus on those associated with obesity

John Nicasio, DO

  • Assistant Professor, Internal Medicine, Tufts University School of Medicine

  • Division of Endocrinology, Diabetes, and Metabolism, Baystate Medical Center

  • Diabetes treatment and complications

  • Thyroid hormone effects on lipid metabolism

John R. Romanelli, MD

  • Assistant Professor, Surgery, Tufts University School of Medicine

  • Medical Director, Bariatric Surgery Program, Baystate Medical Center

  • Neuroendocrine and metabolic regulation of energy balance

  • Natural Orifices Transluminal Endoscopic Surgery

Sabyasachi Sen, MD, PhD

  • Division of Endocrinology, Diabetes, and Metabolism, Baystate Medical Center

  • PI, Pioneer Valley Life Sciences Institute

  • Vascular and Langerhans islet cell biology

  • Endothelial cell dysfunction in diabetes and pre-diabetes

J. Enrique Silva, MD

  • Professor, Internal Medicine, Tufts University School of Medicine

  • Adjunct Professor, Biology, UMass Amherst

  • Chief, Division of Endocrinology, Diabetes, and Metabolism, Baystate Medical Center

  • Molecular and Cellular Biology Program, UMass Amherst

  • Relationships between temperature homeostasis (thermogenesis) and energy balance

  • Neuroendocrine and metabolic regulation of energy balance

  • Metabolic effects of thyroid hormone

Howard A. Smithline, MD

  • Assistant Clinical Professor, Emergency Medicine, Tufts University School of Medicine

  • Emergency Department, Baystate Medical Center

  • Metabolic abnormalities leading to myocardial failure

  • ATP generation in the failing heart