From the East:

Take Exit 6 off the Massachusetts Turnpike.
Beyond the toll booth, turn left on to Route I-291.
Remain on I-291 until it merges with Route I-91 North.
Follow the Northampton sign.
Take Main Street, Exit 10 off Route 91 North.
The hospital will be two blocks straight ahead as you come down the exit ramp.

From the West: 

Take Exit 4 off the Massachusetts Turnpike.
Pick up Route I-91 South after the toll booth.
Stay on Route I-91 South.
Take Birnie Avenue, Exit 11.
From the exit, follow the blue "H" signs to the hospital.

From the North: 

Take Route I-91 southbound.
Take Birnie Avenue, Exit 11.
From the exit, follow the blue "H" signs to the hospital. 

From the South: 

From Route I-91 northbound, take Main Street, Exit 10.
The hospital will be two blocks straight ahead as you come down the exit ramp.