The Effects of Hyperbaric Oxygen on Cell Death in Lymphocytes
and Neutrophils
Barbara Osborne, Ph.D., Veterinary and Animal Sciences, UMass
Eric Granowitz, M.D., Infectious Disease, Baystate
Bishy Ganguly, Graduate Student, Molecular & Cellular Biology,
UMass
This project explores how hyperbaric oxygen helps persistent wounds
to heal. Scientists know that persistent wounds can heal when the
patient is placed in a hyperbaric chamber and exposed to oxygen,
but it is unclear why this treatment works. One problem with persistent,
or chronic wounds, is inflammation caused by a build-up of white
blood cells, which fight infection. These investigators theorize
that hyperbaric oxygen may trigger the death of some white blood
cells, removing the source of inflammation.
Effective Date - November 1, 1997
Identification and Characterization of Cancer-induced Blood Vessel
Endothelial Cell Surface Proteins for Targeting Immunotoxins to
Disrupt the Cancer Vasculature and Induce Cancer Regression
Bruce Jacobson, Ph.D., Biochem. & Molecular Biology, UMass
Richard Baffour, Ph.D., Medical Research, Baystate
The goal of this research is to identify and characterize cell surface
proteins present on the surface of blood vessel endothelial cells
in cancers but not on the endothelial cells in the vessels of normal
tissues.
Effective Date - September 1, 1997
Psychometric Differences in Patients with Alzheimer's Disease
and Vascular Dementia
Geert deVries, Ph.D., Psychology, UMass
Bradley Crenshaw, Ph.D., Neuropsychology Services, Baystate
Patricia Boyle, Graduate Student, Psychology, UMass
The goal of this project is to understand specific changes in mental
functioning that occur in the two most common forms of dementia,
Alzheimer's Disease and ischemic vascular dementia.
Effective Date - August, 1997
Extramural Funding:
Veteran’s Affairs (4/98) - $19,000
Molecular Mechanisms and Genetic Analysis of Sporadic and Heritable
Breast and Ovarian Cancer
Wesley Autio, Ph.D., Extension Service, UMass
Gabriel Cohn, M.D., Director of Reproductive Genetics, Baystate
Timothy Byrne, Graduate Student, Plant & Soil Science, UMass
The objective is to define the role of BRCA-1 gene in sporadic and
familial breast and ovarian cancers and to develop cost effective
methods for screening and identification of patients who have undergone
gene alteration.
Effective Date - August, 1997
Extramural Funding:
NIH (4/98) - $63,000
Regulation of p53 Tumor Suppressor Pathway in Normal and Neoplastic
Breast Tissues
Joseph Jerry, Ph.D., Veterinary & Animal Sciences, UMass
Stephen Naber, M.D., Ph.D., Pathology, Baystate
Jan Pinkas, Graduate Student, Molecular & Cellular Biology,
UMass
The p53 suppressor gene is mutated or expressed aberrantly in over
half of all breast cancers. An objective of this study is to determine
whether expression of the p53 tumor suppressor gene may be inhibited
or enhanced during specific periods of breast development.
Effective Date - January 1, 1997
Extramural Funding:
DPH (1/98) - $56,768
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