CBR Research Grants

Project Summaries—2000

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20082007200620052004200320022001—2000—19991998199719961995

Learning in Preterm Infants
Neil Berthier, Ph.D., Psychology, UMass
Rachel Clifton, Ph.D., Psychology, UMass
Bhavesh Shah, M.D., Neonatal Intensive Care Unit, Baystate

Learning is an important topic with regard to preterm infants because it is related to issues of control and predictability. Because of lack of control over the environment is believed to produce detrimental effects on development, the obvious lack of control experienced by these infants is cause for concern. The question of learning is also important from a basic science perspective because only limited data are available on learning in such young infants. The ability of preterm infants to learn an artificial contingency where the required response is adapted to their capabilities is being investigated.

Effective Date - September 1, 2000

Presentations:
Butler,S.C., O'Sullivan,L.P., Shah, B.L.,& Berthier, N.E.
Learning and Retention in Preterm Infants. Poster presented at the
Pediatric Academic Societies' Annual Meeting, Baltimore, MD, 2001.

O'Sullivan, L., Butler, S., Berthier, N., Clifton, R., Shah, B.
Motherese: Implications for its Importance to Preterm Infants.
Presented at the International Conference on Infancy Studies,
Toronto, Canada, 2002.

Effects of Insulin Resistance on Blood Glucose Uptake During Exercise
Barry Braun, Ph.D., Exercise Science, UMass
Stuart Chipkin, M.D. Endocrinology, Diabetes and Metabolism, Baystate

The overall goal of this collaboration is to gain a deeper understanding of how exercise enhances the actions of insulin to lower blood glucose levels and to apply this information to the prevention and clinical management of non-insulin-dependent diabetes mellitus (NIDDM).

Effective Date - September 1, 2000

Oxalate, Glycolate and Selenium in Neonatal Nutrition, High Resolution Analytical Chemical Methods for the Clinical Study of Premature Infants
Peter Uden, Ph.D., Chemistry, UMass
Gary Rockwell, M.D., Newborn Medicine and Pediatrics, Baystate
Nigel Metcalfe, Graduate Student, Chemistry, UMass

The long-term goal of this clinical research is to improve the prognosis of premature infants by increasing our understanding of kidney stone formation, a problem that occurs in up to 64 percent of premature infants and is associated with persistent defects in kidney function that can be life-threatening. The disorder is characterized by high levels of two biochemicals, oxalate and glycolate, in the infant's urine. The researchers will study the levels of these biochemicals in infants' urine to determine how well the infants can metabolize these biochemicals. The information will be valuable in offering new treatments for pre-term infants.

Effective Date - September 1, 2000

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